METHOD FOR MANUFACTURING THERAPEUTIC IMMUNE CELLS

Invention Novelty

Chimeric antigen receptor (CAR) T cells have so far shown limited efficacy on brain and solid tumors. UCSF investigators have developed a method of manufacturing recombinant immune cells by pre-treating them with a combination of small molecules to increase the number of CAR T cells in the tumor microenvironment and improve the survival of animal models bearing glioma in the brain relative to CAR T cells that have not received the pre-treatment. These results may be applicable to other solid tumors.

Value Proposition

• Increased survival of CAR T cells following the intravenous infusion
• Improved survival of mice bearing brain tumors
• Manufacturing step can be easily incorporated into current manufacturing strategies for CAR T cells

Patent Status

Patent Pending